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Vitamin A, D3 and K2

The Calcium Paradox

The formula in A • D • K is based on scientific research that examined the synergistic effects of vitamins, A, D3, and K2. In her new book, Vitamin K2 and the Calcium Paradox, Kate Rheaume-Bleue, ND argues that the combination of vitamins A, D and K “are intricately interrelated in complex ways that modern science doesn’t yet entirely understand.” So complex, in fact, that she dedicated an entire chapter solely to the interconnectedness and potential health benefits of combining these three important vitamins.


Dr. Rheaume-Bleue also argues that the “bone-building benefits of vitamin D” depend on vitamin K2, and when vitamin D is “assisted by vitamin A,” this relationship “stimulates the production of osteocalcin”, which is activated by vitamin K2.* She contends that these fat-soluble vitamins are “profoundly different” than other nutrients because they bind to proteins, especially K, which allows the proteins to bind to calcium so that it can be better utilized in the body.*

In light of these findings, A • D • K is recommended to help support the following:

  • Bone structure, density and integrity*
  • Proper bone remodeling*
  • Calcium utilization*
  • Cardiovascular function*

The combination of A, D, and K may prove to be an essential tool in supporting bone health during menopause, after an organ transplant, and many other critical periods of a patient’s health history.

The Synergistic Effect of Vitamins A, D, and K

Vitamin A is a fat-soluble vitamin with multiple functions in the body, including normal development, growth and maintenance of the skeleton throughout life.* Vitamin A supports the number and activity of osteoclast cells, which break down bone tissue, an ongoing process of skeletal maintenance called bone remodeling.*




Vitamin A supplements may be one of the only reliable sources of this vitamin. Contrary to popular belief, carrots do not contain any vitamin A. This is due to a lot of misleading information available to the public, according to Dr. Rheaume-Bleue. She claims that a deficiency is far more likely than too much vitamin A, which has been a common belief for a long time due to its fat-soluble properties.

Vitamin D3 (cholecalciferol) is a fat-soluble vitamin that is essential for maintaining normal calcium metabolism.* It supports calcium absorption in the gut and helps maintain adequate serum calcium and phosphate concentrations to enable normal mineralization of bone.* Vitamin D3 also supports cardiovascular function and blood pressure within normal ranges.*

Vitamin K2, known as menaquinone (MK- 7), is the form that has been shown to support normal bone formation.* It is responsible for the carboxylation of specific bone proteins that play a regulatory role in bone metabolism.* The benefit of Vitamin K2 versus K1 is that it works primarily outside of the liver in bones and blood vessels.*

Each capsule ofBioTE® Medical A*D*K contains 5,000 IU of Vitamin A (as Retinyl Palmitate),  5,000 IU of Vitamin D3 (as Cholecalciferol), and 500mcg of Vitamin K2 (as MK-7).

Information provided for educational purposes only.  These statements have not been evaluated by the FDA.  These products are not intended to diagnose, treat, cure or prevent any disease.